Research Topic · Peer-Reviewed

Gene Regulation

Gene regulation is the set of mechanisms that control when, where, and how strongly genes are expressed, determining which proteins a cell produces and thereby shaping development, differentiation, and responses to the environment. It operates at multiple levels, including transcription factors binding to regulatory…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 92× across the literature 🗓 Reviewed July 2026

Overview

Gene regulation is the set of mechanisms that control when, where, and how strongly genes are expressed, determining which proteins a cell produces and thereby shaping development, differentiation, and responses to the environment. It operates at multiple levels, including transcription factors binding to regulatory DNA, chromatin and epigenetic modifications such as DNA methylation, and the action of non-coding RNAs that modulate transcripts after they are made. Regulatory variation, including single-nucleotide polymorphisms in binding sites, can alter expression and contribute to disease susceptibility and adaptation. Research in this area examines computational analyses of regulatory polymorphisms in transcription-factor binding sites and their links to disease and to high-altitude adaptation, and bioinformatic identification of coronary-disease-associated variants and genes. Studies also explore epigenetic regulation in the context of nutrition and chronic pain, the role of circular and non-coding RNAs, and the conservation and clustering of developmental and orthologous genes. Further work considers signalling-linked control of gene expression in plant rooting and antioxidant responses. By connecting regulatory sequence, chromatin state, and RNA-mediated control to phenotype, gene-regulation research clarifies how identical genomes give rise to diverse cell types and conditions, and how disruption of these controls underlies disease, providing targets for diagnosis and intervention within a systems-level understanding of biology.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 92 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Gene Regulation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Systems Biology.

Journal editorial board
Miklos Nyitrai · Hungary Sutopa Dwivedi · United States Leon Bobrowski · Poland

This page summarises published research for orientation; it is not medical or professional advice.