Hem D Shukla

Baltimore, MD 21201,
United States.

Biomarker Discovery (physical principles of the architecture of biological macromolecules, proteins, nucleic acids and their complexes, namely the ene.
Proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines Identification of biomarkers for pancreatic cancer
Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines

Hem D. Shukla is Research Scientist in Department of Pharmaceutical Sciences at University of Maryland and adjunct Professor of Genomics in Notredame of Maryland University.
He has also worked as Research Faculty in Department of Biology at Johns Hopkins University.
Dr. Shukla has worked on proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines and identification of biomarkers for pancreatic cancer.
He has worked on “The Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines and targets for therapeutic intervention”.
He has shown elevated level of Nrf2 transcriptional factor in pancreatic cancer cell lines under oxidative stress which is phosphorylated by protein kinase C and affects phosphatidylinositol 3-kinase and MAP kinase pathways.
After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase, and superoxide dismutase.
The IPA analysis has suggested a potential role of Nrf2 under oxidative stress conditions.
Currently, working as professor in Department of Biology at University of Maryland.
Previously, I have worked as Staff Scientist and Director of Proteomic Core in National Institute on Aging, NIH.
My expertize is on Pancreatic Cancer Biomarker Discovery.