Mouse models are laboratory mice used as experimental systems to study biological processes, disease mechanisms, and potential treatments. Because mice share a large proportion of their genes with humans, reproduce quickly, and can be genetically modified, they are among the most important tools in physiology and bi…
Mouse models are laboratory mice used as experimental systems to study biological processes, disease mechanisms, and potential treatments. Because mice share a large proportion of their genes with humans, reproduce quickly, and can be genetically modified, they are among the most important tools in physiology and biomedical research. Researchers use mouse models to investigate genetics, development, behaviour, and the function of organ systems, and to recreate aspects of human disease in a controlled setting. Genetically engineered mice, such as knockout strains in which a specific gene is removed, allow scientists to determine the role of individual genes in health and disease, while naturally occurring or selectively bred strains provide models of conditions such as ageing, cancer, and metabolic disorders. Mouse models are particularly valuable for studying complex systems including the nervous, immune, and endocrine systems, and for testing the safety and efficacy of interventions before clinical study. Research relevant to this topic includes studies of tumour development in p53 knockout mice, learning and memory in the long-lived Ames dwarf mouse, and the use of animal models to examine immune responses and disease processes. This page gathers peer-reviewed, open-access research in the International Physiology Journal relevant to mouse models and their use in studying physiology and disease.
10 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 10 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Mouse Models, linking to each citing work.