Bone marrow stem cells are the undifferentiated, self-renewing cells resident in bone marrow that maintain blood and connective tissue throughout life. The marrow contains two principal populations: hematopoietic stem cells, which give rise to all blood and immune lineages, and bone marrow mesenchymal stromal cells,…
Bone marrow stem cells are the undifferentiated, self-renewing cells resident in bone marrow that maintain blood and connective tissue throughout life. The marrow contains two principal populations: hematopoietic stem cells, which give rise to all blood and immune lineages, and bone marrow mesenchymal stromal cells, which can differentiate into osteoblasts, chondrocytes, adipocytes, and supporting stroma and which help regulate the hematopoietic niche. Their defining properties are self-renewal and multilineage differentiation, together with paracrine secretion of trophic and immunomodulatory factors that influence tissue repair. These features make bone marrow stem cells central to hematopoietic reconstitution after transplantation and to regenerative and cell-based therapies for tissue injury. Mesenchymal cells from marrow and other sources, including adipose tissue and umbilical cord, are studied for their capacity to repair damaged tissues, modulate immune and inflammatory responses, and serve as building blocks in tissue engineering. Research relevant to this topic examines the effects of bone marrow and adipose mesenchymal stem cells on intestinal injury, mesenchymal cells as a source of specialized cell types such as odontoblasts, biocompatible scaffolds for stem-cell transplantation and neural modeling, the therapeutic potential of adipose-derived mesenchymal stem cells in ovarian aging, and emerging paradigms in regenerative medicine and stem-cell therapy.
11 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 11 articles above have been cited 36 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Bone Marrow Stem Cells, linking to each citing work.