Research Topic · Peer-Reviewed

Modularly Thyroid Cancer

Medullary Thyroid Cancer (the intended term behind this "modularly" label) is a neuroendocrine malignancy arising from the parafollicular C cells of the thyroid rather than from follicular epithelium. Because C cells secrete calcitonin, this hormone serves as a sensitive tumor marker for diagnosis, postoperative sur…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 24× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Medullary Thyroid Cancer (the intended term behind this "modularly" label) is a neuroendocrine malignancy arising from the parafollicular C cells of the thyroid rather than from follicular epithelium. Because C cells secrete calcitonin, this hormone serves as a sensitive tumor marker for diagnosis, postoperative surveillance, and detection of recurrence, alongside carcinoembryonic antigen. Roughly a quarter of cases are hereditary, occurring within multiple endocrine neoplasia type 2 syndromes and driven by germline activating mutations of the RET proto-oncogene; sporadic tumors frequently harbor somatic RET alterations, making RET a central therapeutic target. Management is primarily surgical, with total thyroidectomy and central compartment lymph node dissection, since medullary carcinoma does not concentrate iodine and is therefore unresponsive to radioactive iodine therapy; adequate preoperative evaluation and nodal staging strongly influence outcomes. For advanced or metastatic disease, selective RET inhibitors and multikinase agents have expanded systemic options, and durable responses to targeted therapy have been described even for variants of uncertain significance. Distinguishing medullary carcinoma from differentiated thyroid cancers and from rarer thyroid malignancies guides prognosis and treatment. The journal publishes peer-reviewed research on Thyroid Cancer biology, molecular diagnosis, surgical management, image-guided ablation, and treatment outcomes across Thyroid Cancer subtypes.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Image Guided Ablations for Thyroid Tumours

Nicosia LucaCorresponding author
Division of Breast Radiology, European Institute of Oncology IRCCS, Milan, Italy, European Institute of Oncology IEO, IRCCS, Via Giuseppe Ripamonti, 435 - 20141 Milano MI, Italy
Thyroid Cancer Cited by 2 doi:10.14302/issn.2574-4496.jtc-19-2657
2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986

How this research is being cited

The 12 articles above have been cited 24 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Modularly Thyroid Cancer, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.