Research Topic · Peer-Reviewed

Graves Disease

Graves disease is an autoimmune disorder of the thyroid in which circulating autoantibodies (thyroid-stimulating immunoglobulins) bind and activate the thyrotropin (TSH) receptor on thyroid follicular cells, driving unregulated synthesis and release of thyroxine (T4) and triiodothyronine (T3). It is the most common …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 24× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Graves disease is an autoimmune disorder of the thyroid in which circulating autoantibodies (thyroid-stimulating immunoglobulins) bind and activate the thyrotropin (TSH) receptor on thyroid follicular cells, driving unregulated synthesis and release of thyroxine (T4) and triiodothyronine (T3). It is the most common cause of hyperthyroidism and characteristically presents with diffuse goiter, weight loss, heat intolerance, tachycardia, tremor, and, in a subset of patients, Graves orbitopathy and pretibial myxedema. Diagnosis rests on suppressed TSH with elevated free thyroid hormones, detection of TSH-receptor antibodies, and radioactive iodine uptake or color-flow Doppler demonstrating diffuse hyperfunction. Management options include antithyroid thionamides (methimazole, propylthiouracil), radioiodine ablation, and thyroidectomy, with beta-blockade for adrenergic symptom control. Because untreated thyrotoxicosis can precipitate atrial fibrillation, osteoporosis, and thyroid storm, timely recognition is important, and differentiation from other causes of hyperthyroidism, thyroiditis, and nodular disease is essential. As an organ-specific autoimmune condition, Graves disease also informs broader understanding of thyroid receptor signaling, immune tolerance, and the spectrum of benign and malignant thyroid pathology. This journal publishes peer-reviewed clinical and laboratory research relevant to thyroid disorders and their diagnosis and care.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Exact topic Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986

How this research is being cited

The 12 articles above have been cited 24 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Graves Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.