Research Topic · Peer-Reviewed

Degenerative Diseases

Degenerative diseases are chronic conditions defined by the progressive deterioration of the structure and function of cells, tissues, and organs over time, typically driven by cumulative molecular damage rather than a single acute insult. Their pathogenesis commonly involves oxidative stress, telomere attrition, im…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 46× across the literature 🔖 ISSN 2832-4048 🗓 Reviewed July 2026

Overview

Degenerative diseases are chronic conditions defined by the progressive deterioration of the structure and function of cells, tissues, and organs over time, typically driven by cumulative molecular damage rather than a single acute insult. Their pathogenesis commonly involves oxidative stress, telomere attrition, impaired protein homeostasis, chronic inflammation, and the gradual loss of regenerative capacity, processes closely intertwined with biological ageing. Such diseases affect diverse systems, producing neurodegeneration, age-related macular degeneration, cartilage and joint deterioration, vascular and valvular change, and loss of muscle and skeletal integrity, often with overlapping mechanisms of cellular senescence and accumulated damage. Because their progression is gradual, research emphasises early biomarkers, antioxidant and nutritional strategies, and regenerative approaches, including stem-cell and tissue-repair therapies, alongside the ethical and practical considerations these raise. Understanding the interplay between genetic predisposition, environmental exposure, and lifestyle is central to slowing or modifying disease course. The peer-reviewed research associated with this topic addresses oxidative telomere attrition and nutritional antioxidants in biological ageing, phytochemical strategies for macular degeneration, regenerative and stem-cell therapies, molecular biomarkers, and the role of physical and environmental factors in age-related decline, reflecting the field's focus on the cellular mechanisms of progressive tissue deterioration and the interventions intended to preserve function across the lifespan.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2021

The Use of Metabolomic Tool in Assessing Environmental Exposure

Polyana Rocha Mendes MicheleCorresponding author
Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil
Exact topic International Journal of Occupational and Environmental Medicine doi:10.14302/issn.2690-0904.ijoe-21-3966
2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Exact topic Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 12 articles above have been cited 46 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Degenerative Diseases, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Skeletal Muscle (ISSN 2832-4048).

Journal editorial board
Gerhard Meissner · United States Min Du · United States Jeong-Rae Kim · South Korea

This page summarises published research for orientation; it is not medical or professional advice.