Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection, in which immune, coagulation, and endothelial pathways are activated in a way that injures the body's own tissues. It can progress to septic shock, characterised by circulatory and metabolic derangement, profound hypote…
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection, in which immune, coagulation, and endothelial pathways are activated in a way that injures the body's own tissues. It can progress to septic shock, characterised by circulatory and metabolic derangement, profound hypotension, and elevated lactate reflecting impaired tissue perfusion and anaerobic metabolism. The syndrome arises from bacterial, viral, fungal, or parasitic infection and may complicate pneumonia, the systemic inflammatory response syndrome, and other acute illness, with cytokine release driving widespread inflammation and, in severe cases, multi-organ failure. Recognised sequelae include myocardial dysfunction, acute respiratory distress, acid–base disturbance, and coagulopathy. Management depends on early identification, source control, timely antimicrobial therapy, haemodynamic resuscitation, and organ support, with risk-stratification tools and biomarkers aiding prognosis, and rehabilitation addressing recovery after intensive care. Research relevant to this area spans inflammatory cytokine responses in experimental systemic inflammation, cardiac and respiratory complications of severe sepsis, antimicrobial stewardship in neonatal units, lactic acidosis, biomarkers of disease, and outcome prediction in pneumonia and critical illness. The International Journal of Infection Prevention publishes peer-reviewed research on the pathophysiology, recognition, treatment, and prevention of sepsis and its complications.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Sepsis, linking to each citing work.