Research Topic · Peer-Reviewed

Celiac Disease

Celiac disease is a chronic, immune-mediated enteropathy triggered in genetically susceptible individuals by the ingestion of gluten, the storage protein found in wheat, barley, and rye. In affected people, gluten-derived peptides provoke an adaptive immune response, strongly associated with HLA-DQ2 and HLA-DQ8 hapl…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 22× across the literature 🗓 Reviewed July 2026

Overview

Celiac disease is a chronic, immune-mediated enteropathy triggered in genetically susceptible individuals by the ingestion of gluten, the storage protein found in wheat, barley, and rye. In affected people, gluten-derived peptides provoke an adaptive immune response, strongly associated with HLA-DQ2 and HLA-DQ8 haplotypes, that damages the small-intestinal mucosa, producing villous atrophy, crypt hyperplasia, and intraepithelial lymphocytosis. The resulting malabsorption gives rise to gastrointestinal symptoms such as diarrhea, bloating, and abdominal pain, as well as systemic manifestations including anemia, fatigue, and nutritional deficiencies, while many cases present atypically or silently. Diagnosis rests on serological testing for disease-specific autoantibodies and confirmatory duodenal biopsy, and celiac disease is associated with other autoimmune conditions. The only established treatment is lifelong adherence to a strict gluten-free diet, which permits mucosal healing and symptom resolution, and which has also been explored for related and overlapping conditions. Within the associated literature, gluten- and intestine-related themes include a case report of intestinal malrotation in a suspected celiac patient, the impact of a gluten-free diet on fibromyalgia symptoms, autoimmune polyglandular associations, and gastrointestinal health in relation to nutrition-based intervention. Because untreated disease carries risk of long-term complications, accurate diagnosis and dietary management are central. This journal publishes peer-reviewed research relevant to autoimmune and nutritional gastrointestinal disorders, including celiac disease and gluten-related conditions.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 22 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Celiac Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Human and Animal Intestines.

Journal editorial board
Valentina Discepolo · Italy Wissem MNIF · Saudi Arabia

This page summarises published research for orientation; it is not medical or professional advice.