Research Topic · Peer-Reviewed

Blood-brain Barrier

The blood-brain barrier is a highly selective physiological interface that separates the circulating blood from the extracellular fluid of the central nervous system, protecting the brain by tightly regulating which substances can pass from the bloodstream into neural tissue. It is formed primarily by specialized en…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 30× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

The blood-brain barrier is a highly selective physiological interface that separates the circulating blood from the extracellular fluid of the central nervous system, protecting the brain by tightly regulating which substances can pass from the bloodstream into neural tissue. It is formed primarily by specialized endothelial cells lining the brain's capillaries, joined by tight junctions and supported by pericytes and astrocytes, which together restrict the free movement of molecules and limit the entry of pathogens, toxins, and many drugs. This barrier maintains the stable chemical environment that neurons require to function while still permitting the selective transport of essential nutrients such as glucose and amino acids. The blood-brain barrier is of major importance in oncology and neurology because it both shields the brain and poses a significant obstacle to delivering chemotherapy and other therapeutic agents to brain tumors and central nervous system disease. Research on therapies directed at the brain, including the use of systemic chemotherapy following whole-brain radiotherapy in metastatic disease, reflects the clinical relevance of how effectively treatments can reach the central nervous system. Within Hematology and Oncology Research, the barrier remains a key consideration in treating cancers that affect the brain. This page gathers material relevant to the blood-brain barrier within the oncology and neuroscience literature.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

The Role of Biogenic Amines in Nutrition Toxicology: Review

Ozcelik FatihCorresponding author
University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital, Department of Medical Biochemistry, Istanbul, Turkey
Exact topic International Journal of Nutrition Cited by 20 doi:10.14302/issn.2379-7835.ijn-20-3171
2020

The Novel Coronavirus 2019 (COVID-19): A Narrative Review

Rezapour BarataliCorresponding author
Department of Public Health, Faculty of Health, Assistant Professor, PhD in Health education and promotion, Urmia University of Medical Sciences, Urmia, Iran
Exact topic International Journal of Coronaviruses Cited by 2 doi:10.14302/issn.2692-1537.ijcv-20-3373

How this research is being cited

The 12 articles above have been cited 30 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Blood-brain Barrier, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.