Research Topic · Peer-Reviewed

Polyacrylamide Gel Electrophoresis

Polyacrylamide gel electrophoresis (PAGE) is a widely used separation technique in which proteins or nucleic acids are resolved according to their size, shape, and electrical charge by migration through a polyacrylamide gel under an electric field. The differential movement of molecules through the gel allows resear…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 23× across the literature 🔖 ISSN 2694-1198 🗓 Reviewed July 2026

Overview

Polyacrylamide gel electrophoresis (PAGE) is a widely used separation technique in which proteins or nucleic acids are resolved according to their size, shape, and electrical charge by migration through a polyacrylamide gel under an electric field. The differential movement of molecules through the gel allows researchers to identify, quantify, and characterize biomolecules and to analyze their structure and function in biological processes. In Genetic Engineering and molecular biology, PAGE is essential for examining recombinant proteins, nucleic acids, and the products of cloning, expression, and mutation studies, and it has applications extending to diagnostics and forensic identification. Denaturing and native formats enable assessment of molecular weight, purity, subunit composition, and molecular interactions. Research relevant to this topic includes proteomic and genomic techniques applied to medical research, cancer diagnostics, and personalized medicine, alongside broader treatments of the proteome and proteomics. Reported studies also employ protein analysis to investigate disulfide-bond-dependent dimerization and DNA binding of plant GAGA-factor transcription factors, the identification of somatic mutations in interferon-gamma signaling molecules, the characterization of a myotoxic enzyme isolated from snake venom, regulation of chemokines and kinases by signaling proteins, and protein stability in cell culture. These examples show how gel-based separation supports the analysis of gene products, molecular biomarkers, and engineered proteins across the molecular life sciences.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Exact topic Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 12 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Polyacrylamide Gel Electrophoresis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Genetic Engineering (ISSN 2694-1198).

Journal editorial board
Gabriela Roca · Germany Khalid Al-Nedawi · Canada Giuliana Giardino · Italy

This page summarises published research for orientation; it is not medical or professional advice.