Toxicity testing methods are the approaches used to evaluate whether a chemical, drug, or other substance can cause harm to living organisms, and to characterize the nature and extent of that harm. These methods are central to assessing the safety of pharmaceuticals, industrial chemicals, consumer products, food add…
Toxicity testing methods are the approaches used to evaluate whether a chemical, drug, or other substance can cause harm to living organisms, and to characterize the nature and extent of that harm. These methods are central to assessing the safety of pharmaceuticals, industrial chemicals, consumer products, food additives, and environmental contaminants. Toxicity testing can be carried out using several broad strategies, including in vitro tests using cells or tissues, in vivo studies in whole organisms, and ex vivo and computational approaches, each suited to different questions and stages of assessment. Such tests examine endpoints like the dose at which effects appear, the organs or systems affected, and effects over different exposure durations, helping to establish how toxic a substance is and at what levels it poses a risk. The results inform safety standards, regulatory decisions, exposure limits, and the design of safer compounds, and methods continue to develop toward greater relevance, sensitivity, and efficiency, including approaches that reduce reliance on animal testing. Research on toxicity testing addresses the design and validation of these methods, the interpretation of toxic effects, and their application to specific substances. As part of Experimental and Clinical Toxicology, this open-access page gathers peer-reviewed research relevant to the evaluation of toxic effects, exposure and dose assessment, and the methods used to study how substances affect living systems.
4 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 4 articles above have been cited 25 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Toxicity Testing Methods, linking to each citing work.