What is Epidermal Growth Factor?

Epidermal Growth Factor: Research & Overview | Clinical Case Reports and Images

Overview

Epidermal growth factor (EGF) is a 53-amino-acid polypeptide that binds the epidermal growth factor receptor (EGFR/ErbB1), a receptor tyrosine kinase whose activation triggers downstream RAS-MAPK and PI3K-AKT signaling to drive cell proliferation, survival, migration, and differentiation. The EGF/EGFR axis is central to epithelial tissue maintenance, wound healing, and angiogenesis, and its dysregulation contributes to oncogenesis, making EGFR a major target for tyrosine-kinase inhibitors and monoclonal antibodies in cancer therapy. Research associated with this topic reflects both the regenerative and oncological dimensions of growth-factor biology. Studies address wound healing and tissue repair, including the influence of acute versus chronic wound fluid in three-dimensional in-vitro models and amniotic membrane treatment of severe epidermal injury, alongside tissue-engineering approaches using stem cells. Oncology-focused work examines EGFR-directed therapeutics such as erlotinib and lapatinib, proteomic responses to targeted agents, biomarker discovery in carcinomas and sarcomas, and signaling pathways governing metastasis and epithelial-mesenchymal transition. Collectively, this peer-reviewed literature illustrates how EGF-related signaling informs regenerative medicine, molecular oncology, and the development and evaluation of receptor-targeted treatments across human and comparative models.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

Treatment of a Severe Pediatric Lyell Syndrome with Amniotic Membrane: Case Report and Histological Findings

Pontini A.Corresponding author

Department of Neuroscience Specialties, Plastic Reconstructive Surgery and Burn Unit – Padova University Hospital

Exact topic Tissue Repair and Regeneration Cited by 2 doi:10.14302/issn.2640-6403.jtrr-18-2442

2017

Acute and Chronic Wound Fluid Inversely Influence Wound Healing in an in-Vitro 3D Wound Model

Manuela BesserCorresponding author

University Witten/Herdecke, Centre for Biomedical Education and Research (ZBAF), Dpt. Of Translational Wound Research

Exact topic Tissue Repair and Regeneration Cited by 22 doi:10.14302/issn.2640-6403.jtrr-17-1818

2015

Erlotinib Associated Trichomegaly in a Patient with Chronic Latanoprost Use

CL Jr CowanCorresponding author

Department of Ophthalmology, Washington, D.C. Veterans Administration Medical Center, Washington, D.C.

Exact topic Hematology and Oncology Research doi:10.14302/issn.2372-6601.jhor-15-667

2019

Robust Sampling of Defective Pathways in Parkinson Disease

Luis Fernández-Martínez JuanCorresponding author

Group of Inverse Problems, Optimization and Machine Learning. Department of Mathematics. C/ Federico García Lorca, 18. 33007 Oviedo. University of Oviedo. Spain

Exact topic Medical Informatics and Decision Making Cited by 2 doi:10.14302/issn.2641-5526.jmid-18-2529

2019

Evaluation of Anti-Aging Activity of the Biofield Energy Treated Novel Test Formulation Using SIRT1 and Telomerase Activity in in Vitro Model

Jana SnehasisCorresponding author

Trivedi Science Research Laboratory Pvt. Ltd., Thane (W), India

Exact topic Aging Research And Healthcare Cited by 3 doi:10.14302/issn.2474-7785.jarh-19-2994

2015

Medullary Thyroid Cancer: Is the Adequacy of Pre-Operative Evaluation Influenced by Training Background?

Alhefdhi AmalCorresponding author

Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI

Exact topic Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-14-395

2015

Laryngeal Tissue Engineering using Rabbit Adipose Derived Stem Cells in Fibrin: A Pre-Clinical Model

Shiba TravisCorresponding author

Department of Head and Neck Surgery, University of California- Los Angeles, Los Angeles, California, U.S.A

Exact topic Otolaryngology Advances Cited by 8 doi:10.14302/issn.2379-8572.joa-14-611

2015

Overexpression of Prostate Apoptosis Response Protein-4 In Colon Cancer Cells Can Inhibit Metastasis by Upregulating E-cadherin Expression

B. Irby RosalynCorresponding author

Department of Medicine Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033. &Denotes equal contribution

Exact topic Colon And Rectal Cancer Cited by 4 doi:10.14302/issn.2471-7061.jcrc-14-574

2014

Identification of Novel Biomarker for Human Uterine Leiomyosarcoma

Hayashi TakumaCorresponding author

Dept. of Immunology and Infectious Disease, Shinshu University, School of Medicine, Matsumoto, Nagano 390-8621, Japan

Exact topic Hematology and Oncology Research Cited by 1 doi:10.14302/issn.2372-6601.jhor-13-379

2013

Determination of the Proteomic Response to Lapatinib Treatment using a Comprehensive and Reproducible Ion-Current-Based Proteomics Strategy

O’Connell KathleenCorresponding author

Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC,

Exact topic Proteomics and Genomics Research Cited by 3 doi:10.14302/issn.2326-0793.jpgr-13-257

2014

Correlation of Oncotype DX Recurrence Score with the Expression of Insulin Receptor Substrate Proteins in Estrogen Receptor + Breast Cancer

Khan AshrafCorresponding author

Departments of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA 01605, USA

Exact topic Cancer Genetics And Biomarkers Cited by 1 doi:10.14302/issn.2572-3030.jcgb-13-369

2017

Canine Periosteal Osteosarcoma

Noronha de Toledo GabrielaCorresponding author

Department of Clinic and Veterinary Surgery, School of Agricultural and Veterinary Sciences (FCAV), Universidade Estadual Paulista – UNESP, Campus Jaboticabal, SP, Brazil.

Exact topic Veterinary Healthcare Cited by 2 doi:10.14302/issn.2575-1212.jvhc-17-1574

How this research is being cited

The 12 articles above have been cited 48 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

BDDN: bayesian dynamic differential network analysis in cancer proteomics

2026 · BMC Bioinformatics
Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro

Rima Nuwayhid et al. · 2025 · Frontiers in Bioengineering and Biotechnology
Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro

2025 · Frontiers in Bioengineering and Biotechnology
Safety and Toxicity Evaluation of Stem Cell‐Based Vocal Fold Implant in Swine

2025 · The Laryngoscope
Biological properties and surgical applications of the human amniotic membrane

J. R. Muñoz-Torres et al. · 2023 · Frontiers in Bioengineering and Biotechnology
Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer

2023 · Journal of Breast Cancer
Biological properties and surgical applications of the human amniotic membrane

2023 · Frontiers in Bioengineering and Biotechnology
Clinically relevant in vitro biofilm models: A need to mimic and recapitulate the host environment

H. Vyas et al. · 2022 · Biofilm

A sample of recent works citing this journal's research on Epidermal Growth Factor, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Clinical Case Reports and Images (ISSN 2641-5518).

Journal editorial board

Majaz Moonis · United States Berton Alessandra · Italy Young-Kyun Lee · South Korea

This page summarises published research for orientation; it is not medical or professional advice.

Epidermal Growth Factor

Overview

Research published in this journal

How this research is being cited

Editorial oversight

Related topics