International Journal of Inflammation Research
Aims & Scope
International Journal of Inflammation Research publishes peer-reviewed research on inflammation — how inflammatory responses begin, how they are regulated, and how they resolve — across molecules, cells, tissues, organs and disease contexts, and welcomes basic, translational and clinical investigation from research groups worldwide.
The subject
Inflammation as the object of study
The journal takes inflammation itself as its subject, studied at whatever level and by whatever method a question requires. Work is considered on the contribution it makes to understanding, measuring, preventing, diagnosing, managing, treating or evaluating inflammation and inflammatory disease, not on the organ, model system, discipline or study design it happens to come from.
Mechanism and regulation
The molecular basis of an inflammatory response and the controls that shape it.
- Cytokines, chemokines, lipid mediators and their receptors
- Pattern-recognition signaling, inflammasome biology and downstream transcriptional control, including NF-κB
- Metabolic, epigenetic and post-transcriptional regulation of inflammatory cells
- Negative regulation, tolerance and the restraint of an ongoing response
Cells, tissues and organs
Who responds, where, and what the local environment contributes.
- Innate and adaptive immune cell populations and their recruitment, activation and phenotype
- Resident epithelial, endothelial, stromal and neural cells as participants rather than bystanders
- Tissue and organ context, barrier function and the microenvironment of an inflamed site
Disease contexts
Conditions in which inflammation drives, sustains or modifies pathology.
- Immune-mediated, autoimmune and autoinflammatory disease
- Infection-associated and injury-associated inflammation
- Inflammation in cardiovascular, metabolic, neurological, respiratory, renal, dermatological, musculoskeletal, gastrointestinal and malignant disease
- The experimental, animal and clinical settings in which these are investigated
Resolution and repair
How an inflammatory response ends, and what determines what follows.
- Pro-resolving mediators, efferocytosis and the active programs of resolution
- Tissue repair, remodeling and fibrosis
- The transition between resolution and persistent inflammation
Measurement and intervention run through all four: biomarkers, imaging, models and analytical methods that make an inflammatory process observable, and anti-inflammatory or immunomodulatory strategies evaluated in preclinical or clinical settings. Methodological and resource contributions are considered on the same terms as primary research.
Fit
How fit is judged
The question
A manuscript fits when inflammation is scientifically central to the work — when the study is designed to make a substantive contribution to understanding, measuring, preventing, diagnosing, managing, treating, evaluating or otherwise investigating inflammation or an inflammatory disease process.
The evidence
Scope and evidence are judged separately: eligibility does not depend on a particular method, and claims are assessed against the design that produced them. Laboratory, animal, translational, clinical, epidemiological, methodological, outcomes and health-services studies are all eligible. Preclinical findings are presented as preclinical.
The boundary
Inflammation has to be central to the work rather than adjacent to it. Where it appears only as a background covariate, as one measurement among several with no bearing on the study's claim, or as a secondary interpretation the data do not support, a journal in the work's primary field will usually serve it better. The editors are glad to advise on fit before submission.
Breadth
The journal's published record illustrates this remit; it does not define it. A topic that has not appeared before is considered on the same terms as one that has.
All submissions undergo initial editorial screening. Manuscripts that meet the journal's scope and minimum requirements proceed to independent peer review. Single-blind by default; double-blind review is available on request. Manuscripts that proceed to external peer review are normally evaluated by at least two independent subject-matter experts. Editorial decisions are based on scope, scientific quality, methodological rigor, ethical compliance, reporting quality, and relevance to the journal.
Where to go next
Pages
- Instructions for AuthorsManuscript preparation and submission requirements.
- Editorial PoliciesThe policies governing review, ethics and publication.
- About the JournalWhat the journal is, who it serves, and how it is run.
Also useful
- Call for PapersWhat the journal is inviting.
- Editorial BoardThe editors responsible for review.
- Article Processing ChargesWhat is charged, and when.