About the journal
About the Journal of Experimental and Clinical Toxicology
The Journal of Experimental and Clinical Toxicology publishes peer-reviewed research on how toxic substances act on biological systems, and on how poisoning is recognized, assessed, treated and prevented.
It exists so that mechanistic work and clinical experience are read beside each other, each at the strength of its own evidence.
Journal record
- Title
- Journal of Experimental and Clinical Toxicology (JECT)
- ISSN
- 2641-7669
- Publisher
- Open Access Pub
- Access
- Open access; every article is free to read on publication
- Review
- Peer reviewed
- Fields
- Experimental toxicology · Clinical toxicology
Why it exists
A journal for the mechanism and for the patient
Toxicology advances on two fronts that do not always meet. One asks what a substance does to cells, tissues and whole organisms under controlled conditions; the other asks what happens to a person who has been exposed, and what can be done for them. Work of both kinds appears in this journal, and the distance between them is stated plainly rather than smoothed over.
The journal's record spans mechanistic and cellular investigation, toxicokinetics and metabolism, organ-specific and environmental toxicology, analytical and clinical assessment, and the care of people who have been exposed.
Published work illustrates that range; the subject boundary is set by the field itself. A study contained entirely within experimental toxicology and a study contained entirely within clinical practice each belong here on their own terms, and neither is asked to carry the other.
The scientific remit
Two domains, one published record
Experimental toxicology
Mechanisms of molecular and cellular injury, dose–response characterization, toxicokinetics and metabolism, target-organ effects, genotoxicity and cell-death pathways, environmental contaminants and natural toxins, and the analytical, in vitro and computational methods that measure them.
- Mechanism
- Dose response
- Toxicokinetics
- Biomarkers
- Assay methods
Clinical toxicology
Recognition and assessment of poisoning and envenomation, adverse drug effects, antidotal and supportive management, occupational and environmental exposure in patients, prevention, and case-based reports that document how an exposure presented and how it was managed.
- Poisoning
- Assessment
- Antidotes
- Management
- Prevention
Where the two meet
Both domains ask one question — what does this substance do, at this dose, to this system — and both are held to evidence of the kind that can answer it.
Experimental models establish mechanism and plausibility. Demonstrated clinical benefit is established separately, in studies conducted in patients, and the journal keeps that distinction visible in how findings are reported.
Readership
Who the journal is written for
- Toxicologists and pharmacologists
- Mechanistic findings, kinetics and target-organ effects reported in enough detail to build on.
- Analytical and biomonitoring scientists
- Methods, matrices and measurement conditions described so that results can be compared.
- Clinicians in emergency medicine, intensive care and poison information services
- Assessment, management and clinical course, including reports of uncommon presentations.
- Environmental and occupational health scientists
- Exposure in natural and working environments, and the biological effects that follow it.
- Regulatory and risk-assessment scientists
- Dose–response and mechanism presented in a form that supports careful appraisal.
- Researchers entering the field
- Complete methods and stated limits, which make a study usable by someone learning to design one.
Editorial responsibility
Claims are published at the strength of their evidence
Toxicology carries a particular obligation: the same finding can inform a safety limit, a treatment decision or a regulatory judgment, and each of those uses demands a different weight of evidence. The journal's first editorial responsibility is to keep a claim and its support in proportion.
Findings from cells, tissues and animal models are presented as what they are — mechanism, plausibility and a direction for further study. Case-based clinical reports describe what was observed in the patients they concern. Where a manuscript reaches past what its design can support, the editors ask for the claim to be returned to the evidence.
The same care applies to exposure and dose. Concentrations, routes, durations and conditions belong in the report, because a toxic effect is meaningful only alongside the exposure that produced it.
How manuscripts are handled
- Screening
- All submissions undergo initial editorial screening. Manuscripts that meet the journal's scope and minimum requirements proceed to independent peer review.
- Review model
- Single-blind by default; double-blind review is available on request.
- Reviewers
- Manuscripts that proceed to external peer review are normally evaluated by at least two independent subject-matter experts.
- Decisions
- Editorial decisions are based on scope, scientific quality, methodological rigor, ethical compliance, reporting quality, and relevance to the journal. Decisions remain independent of fees, membership, editorial roles and paid services.
Next
Reading the journal, and writing for it
The Aims and Scope is the authoritative acceptance boundary; the published record illustrates it. The scope statement sets out the subject boundary in full, and the submission page gives the routes open to authors.
Current and past research published by the journal.
The subject boundary and the work the journal invites.
How manuscripts reach the editorial office.
Journal of Experimental and Clinical Toxicology · ISSN 2641-7669 · Published by Open Access Pub.